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Document 3069
DOCN M94A3069
TI Progression of HIV infection from the moment of probable transmission.
DT 9412
AU Meira DA; Souza LR; Marcondes-Machado J; Zacchi B; Faculdade de Medicina
de Botucatu, UNESP, Brazil.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):160 (abstract no. PB0066). Unique
Identifier : AIDSLINE ICA10/94369506
AB OBJECTIVE: In Brazil little is known about the progression of AIDS
infection considered from the moment of transmission. The objective of
the study was to observe this situation. METHODS: 65 HIV infected
individuals with probable moment of contagion determined were studied,
after a 8-year follow up period. Mechanisms of transmission were
defined. The moment of diagnosis, onset of simptoms, last medical
examination and death were computed. Opportunistic infections during
follow up and at autopsy were considered. CD4+ cells were counted at
diagnosis and last medical examination. Results were expressed through
median values. RESULTS: One patients had acute infection three months
after transmission and CD4+ cell count of 778/mm3. Eighteen patients
died 65 months after contagion, with 127 CD4+/mm3. They were diagnosed
60 months after transmission with 165 CD4+ cells/mm3. Survivors without
opportunistic infections were diagnosed 36 months after transmission
with 512 CD4+ cells/mm3 and were last examined one year later, with 460
CD4+ cells/mm3. Survivors with opportunistic infections had been
diagnosed 72 months after transmission, with 273 CD4+ cells/mm3.
DISCUSSION AND CONCLUSIONS: Time of survival and CD4+ cells count were
different among survivors and individuals who died, although there was
no difference among them concerning opportunistic infections, what could
be due to altered CD4+ cell function as well. Further studies are needed
to categorize these patients for TH1 and TH2 type responses to assess
CD4+ cells function.
DE Brazil Follow-Up Studies Human HIV
Infections/IMMUNOLOGY/MORTALITY/*TRANSMISSION Leukocyte Count Survival
Rate T4 Lymphocytes/*IMMUNOLOGY MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).